By detecting lipid oxidation, the research team found that lipid oxidation in lysosomes is the cause of ferroptosis, iron mediated cell death. This results to leakage of iron from lysosomes which ...

RAB7A plays a central role in the final stages of autophagy, facilitating autophagosome-lysosome fusion, lysosome positioning, and cargo degradation. Its activation by guanine nucleotide exchange ...