Hyperammonemia is a condition in which a person has elevated levels of ammonia. Typical symptoms include irritability, vomiting, confusion, and other effects of swelling in the brain.

Higher than normal blood ammonia levels are called hyperammonemia. Acceptable levels depend on age and sex but range from about 42 µg/dL in infants to 200 µg/dL adults assigned male at birth ...

Historically, survival among patients with urea-cycle disorders was poor after episodes of hyperammonemia; most children with a severe enzyme deficiency died as neonates — and few survived ...

Tests revealed hyperammonemia of 62 mcmol/L (< 30 mcmol/L). “His ammonia levels continued to increase, and his encephalopathy continued to worsen despite treatment with lactulose and rifaximin ...

Editorial Alternative-Pathway Therapy for Hyperammonemia Author: Vivian E. Shih, M.D. Author Info & Affiliations Published May 31, 2007 N Engl J Med 2007;356: 2321 - 2322 ...

Hyperinsulinism and hyperammonemia syndrome has been reported as a cause of moderately severe hyperinsulinism with diffuse involvement of the pancreas. The disorder is caused by gain of function ...

Recordati Rare Diseases: Carbaglu® (carglumic acid) tablets 200mg receives U.S. FDA approval for a new indication to treat acute hyperammonemia associated with propionic acidemia and ...

We believe that the factors that should be considered include symptoms attributable to hyperammonemia (i.e., encephalopathy) or an underlying metabolic disorder, the magnitude of the increase in ...

Hyperammonemia is a life-threatening condition, as elevated ammonia is a toxin especially on the central nervous system. If not identified and treated rapidly, the newborn will have irreversible ...

Synlogic Doses First Patient in Phase 1b/2a Trial of SYNB1020 for Treatment of Hyperammonemia in Patients with Cirrhosis – First clinical trial of a Synthetic Biotic™ Medicine in patients – ...

Synlogic announced that the Food and Drug Administration (FDA) has granted Fast Track Designation to their investigational drug SYNB1020 for the treatment of hyperammonemia due to urea cycle ...