Higher body temperature alters key protein in autoinflammatory disorder Groundbreaking research offers insights into understanding the inflammatory disorder mevalonate kinase deficiency, and ...

Mevalonate kinase deficiency (MKD) is a disease that runs in families. A problem with your immune system causes attacks of fever and symptoms like swollen glands, chills, and belly pain every few ...

Journal reference: Munoz, M.A., et al. (2022) Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency.

Australian scientists have shown, for the first time, that a family of untethered proteins builds up in the cells of children with a rare and serious genetic condition, known as mevalonate kinase ...

Elevated core body temperatures may cause bursts of inflammation in individuals with rare autoinflammatory mevalonate kinase deficiency (MKD) via a unique molecular mechanism, reports a study ...

The gene mutation that causes HIDS affects the shape of the MVK protein, making it unstable. This keeps it from working the way normal MVK would. Researchers aren’t sure what triggers HIDS symptoms.

Cullgen Announces First-In-Human Dose in Phase I/II Trial of CG001419, a First-in-Class TRK Protein Degrader for Treatment of Cancer Patients CG001419 is Cullgen’s first protein degrader to ...

The recessive disorder, called mevalonate kinase deficiency (MKD), is caused by mutations in the gene for mevalonate kinase, an essential enzyme present in all cells in the body.