We show here that in a transgenic mouse model, inflammatory mediators induced expression of FcαRI on Kupffer cells ... of oxygen radicals in human polymorphonuclear cells, which was inhibited ...

Every tissue in the human body has an immune cell in it ... special mice with which they could easily clear all Kupffer cells from the liver, without disturbing other cell types.

today announced that it is adding high-purity Kupffer cells to its portfolio of human primary hepatic cells to support liver disease drug discovery and development and help predict adverse drug ...

The liver MPS is utilized in CN Bio’s PhysioMimix DILI assay. It is made up of primary human hepatocytes (PHH) and Kupffer cells (HKC), cultured under flow perfusion on 3D scaffolds and can ...

If Kupffer cells (KCs), a specific kind of immune ... as the body's central immunological organ. The liver is instrumental in keeping the human bloodstream free of pathogens -- bacteria, viruses ...

The discovery made in mice was also validated in human tissue samples ... and cholesterol in the liver. Bulk and single-cell RNA sequencing revealed a Kupffer-cell-specific transcriptional ...

The kit uses primary human hepatocytes and Kupffer cells to mimic human liver function and immune responses, supporting detailed profiling of underlying mechanisms of DILI and key biomarker ...

Additional data in mice, minipigs, and non-human primates demonstrated ... Delivery of Cas9 to Disrupt NLRP3 in Kupffer Cells and Ameliorate Acute Liver Injury ARMMs loaded with Cas9 and a guide ...

A new study in mice and human cell samples ... The remaining liver structure consists of nonparenchymal cells, including endothelial cells, stellate cells, Kupffer cells, and lymphocytes.” ...

So, Zongwei Cai, Chunmiao Zheng and colleagues wanted to examine the molecular-level and metabolic impacts when human lung and liver cells are exposed to similarly sized nanoplastics. The researchers ...