While the Hulk has been defeated many times in the past, it is rare for an enemy to beat him using only physicality, something that Leader's deranged brother Madman was able to do in just one punch.

As seen in Hulk #1, written by Jeph Loeb, with art by Ed McGuinness, Red Hulk's first punch comes during a fight with the Abomination, one that Leonard Samson and She-Hulk are investigating.