Abexinostat, an HDAC2 inhibitor, restores chromatin AC ... supporting its role in RCC pathophysiology. AC, acetylation; HDAC2, histone deacetylase 2; HIF-α, hypoxia-inducible factor 1-alpha; RCC, ...

Having found that in biomedical research, the Bird Rock resident and scientist at La Jolla’s Sanford Burnham Prebys has ...

Chronic hepatitis B virus (HBV) infection continues to pose a major global health threat. The virus evades immune responses and antiviral therapies due to the persistence of covalently closed circular ...

Hepatitis B virus infection remains one of the leading causes of liver disease, including cirrhosis and hepatocellular carcinoma.

These include DNA methyltransferase and histone deacetylase (HDAC) inhibitors. Further candidates, including inhibitors of acetyl-lysine readers (bromodomain-containing proteins), are undergoing ...

Butyrate, in particular, is known for its dual role as a metabolic substrate and histone deacetylase (HDAC) inhibitor. This duality enables it to selectively regulate gene expression by promoting ...

(UC San Diego) Viracta Therapeutics announced the closure of a phase II trial of its combination therapy of the histone deacetylase inhibitor nanatinostat and the antiviral agent valganciclovir ...

We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. Prior to this trial, CS014 had positive outcomes in ...

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I ...