Introduction Histamine was noted as a mediator of allergic reactions in the early 1900s; the search for effective histamine H 1 -receptor agonists continues. Antihistamines are considered first ...

The histamine receptor family looks to also hold the promise of GPCRs as superb drug targets with two receptor subtypes (H 1 and H 2) addressed by blockbuster drugs, the third subtype (H 3 ...

The outer surface of many of our cells, including those in the airways, has a protein called the H1 receptor. This protein attaches to histamine, an organic compound involved in immune responses.

Combined Blockade of the Histamine H1 and H4 Receptor Suppresses Peanut-Induced Intestinal Anaphylaxis by Regulating Dendritic Cell Function. Allergy, 2016; DOI: 10.1111/all.12904 ...

First, some more about the H1 receptor protein. It binds to histamine and is found is various tissues in the body, including the brain, and plays an important role in the immune system.

The present study was designed to delineate the immunomodulatory role of histamine receptors (H1- and H2-) on induction of antibody response to sheep red blood cells (SRBC), as well as the ...

Histamine has been recognized as being pivotal in regulating sleep and wakefulness through its interaction with the H1 and H3 receptors. 17 H1 receptor agonists induce wakefulness, and H1 receptor ...

Predicting and Establishing the Clinical Efficacy of a Histamine H1-Receptor Antagonist Desloratadine, the Model Paradigm Glenis Scadding Disclosures Clin Drug Invest. 2005;25 (3):153-164. Conclusions ...

More information: Meiqin Wang et al, Combined Blockade of the Histamine H1 and H4 Receptor Suppresses Peanut-Induced Intestinal Anaphylaxis by Regulating Dendritic Cell Function, Allergy (2016).