Researchers from the University of Michigan Rogel Cancer Center developed a new mouse model that shows CDK12 acts as a tumor suppressor to drive high-grade serous carcinoma arising in the mouse ...

Source Reference: Penn CA, Alvarez RD "Current issues in the management of patients with newly diagnosed advanced-stage high-grade serous carcinoma of the ovary" JCO Oncol Pract 2023; 19: 116-122.

The prognosis is particularly poor in ovarian high grade serous carcinoma (HGSC), a subtype of ovarian cancer. Less than 40% of patients with this subtype survive five years after their diagnosis.

A recent study characterized the expression of ADC targets across ovarian cancer histotypes. Findings suggest ...

Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma Authors: Steffen Böhm ...

BOSTON — Patients with non- BRCA gene mutations undergoing risk-reduction surgery to prevent tubo-ovarian cancers showed no signs of tubo-ovarian high-grade serous carcinoma or serous tubal ...

The 575 ovarian cancer specimens comprised 337 high-grade serous, 30 low-grade serous, 60 mucinous, 68 endometrioid, 53 clear cell, and 16 borderline carcinomas.

Discovery of a subset of high-risk progenitor cells that reside in fallopian tube supportive tissue, or stroma, could pave the way for better approaches to prevent and detect high-grade serous ...

A group from Nagoya University in Japan has discovered previously unidentified ovarian cancer-specific membrane proteins. Their findings suggest a new strategy to diagnose ovarian cancer.