“Sertonin plays a fundamental role in regulating the body’s main thermostat, the hypothalamus,” says Dr. Wortzel. “SSRIs [are] obviously going to have a number of effects on the body’s ability to ...

Heat intolerance happens if the body can't regulate its temperature, which is normally around 98.6 degrees. Dysautonomia, or autonomic dysfunction, is a common underlying cause of heat intolerance.

Heat intolerance is a side effect of many common medications, including selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs).

Heat intolerance Heat intolerance typically occurs when your body is having a hard time regulating its temperature, and in turn, people can develop a sensitivity to heat and experience discomfort ...

Warning to antidepressant users as heat wave temperatures hit 100 degrees By McKenzie Beard Published June 24, 2025, 10:17 a.m. ET ...

But for some, the effects of triple-digit heat are worse than others. Certain medications — like antidepressants — cause excessive sweating as a side effect, according to the Cleveland Clinic.

Hot weather can affect people on stimulants because their executive functioning is impaired by the heat, in addition to experiencing heat intolerance. Warning signs for this can look like ...

Symptoms for heat intolerance include excessive sweating or not sweating enough, lightheadedness, dizziness, nausea, vomiting, fatigue, mental status changes or confusion, Barbee said.

Heat intolerance is a common side effect of medications like SSRIs. Here’s what to watch out for, and how to stay cool.