Introduction Histamine was noted as a mediator of allergic reactions in the early 1900s; the search for effective histamine H 1 -receptor agonists continues.

Desloratadine is a long-acting tricyclic histamine antagonist with selective H 1 -receptor histamine antagonist activity. Desloratadine inhibited histamine release from human mast cells in vitro.

New drugs targeting the histamine H4 receptor are also undergoing clinical trials. In the near future, it is possible that drug therapy for allergy is a combination of H1 and H4 receptor blockers.

The present study was designed to delineate the immunomodulatory role of histamine receptors (H1- and H2-) on induction of antibody response to sheep red blood cells (SRBC), as well as the ...

Specifically they combined the ring-butynylhydroxyurea pharmacophore of the 5-LO inhibitors, ABT-761 and CMI-977, with the benzhydryl piperazine pharmacophore of the H1 antagonists cetirizine and ...

Premedication, including a histamine-1 receptor (H 1) antagonist, is recommended to all patients treated with paclitaxel chemotherapy to reduce the incidence of hypersensitivity reactions (HSRs).

Predicting and Establishing the Clinical Efficacy of a Histamine H1-Receptor Antagonist Desloratadine, the Model Paradigm Glenis Scadding Disclosures Clin Drug Invest. 2005;25 (3):153-164. Conclusions ...