First, gram-negative bacteria have a thin cell wall that is about 1.5 to 10 nanometers across, whereas gram-positive bacteria have a thick cell wall measuring about 20 to 80 nanometers.

Zosurabalpin is able to destroy Gram-negative bacteria by jamming LPS molecules inside the bacteria, weakening its membrane. It is the first of its class of antibiotics, and the first new class of ...

In recent decades, more antibiotics have been developed to treat Gram-positive infections, which are typically less harmful and less resistant to antibiotics than Gram-negative bacteria, Lobritz said.

Gram-negative bacteria, in particular, possess an additional lipid bilayer, the OM, which is impermeable to many antibiotics, thereby limiting treatment options.

New antibiotic targets only gram-negative bacteria, sparing the gut Paul Hergenrother’s lab discovered a compound that leaves commensal bacteria alone by Rowan Walrath May 29, 2024 3 min read Share ...

Medical Research Thu 4 Jan 2024 The drug targets gram-negative bacteria which are resistant to many common antibiotics. (Supplied: Menzies School of Health Research) ...