In this study, we demonstrated that the glutathione metabolism pathway is highly enriched in ESCC cells compared with normal esophageal epithelial cells in an in vivo mouse model. In addition ...

"Our in vitro findings suggest that the disruption of Nrf2-driven glutathione synthesis pathway establishes synergistic ... which disrupted glutathione metabolism and established synthetic ...

Glutathione (GSH), best known for ... “The antioxidative GSH pathway thus plays an unexpected role in metabolic integration and reprogramming during inflammatory T cell responses.” ...

"To investigate the molecular function of the cellular reducing agent GSH in the metabolic ... lacking either glutathione or glutathione peroxidase 4, a distinctive signaling pathway is engaged ...

Various molecular pathways, such as glutathione peroxidase 4 (GPX4) inhibition, iron metabolism deregulation, and polyunsaturated fatty acid metabolism, converge to regulate ferroptosis.

A statistically significant improvement in antioxidant status, as measured by serum glutathione level and ... of cysteine to the cells via normal metabolic pathways. By providing abundant cysteine ...