One issue with current diabetes treatment is it uncouples insulin release from glucose sensing, Merrins said. Insulin levels become dependent on drug dosage rather than the blood glucose level the ...

Glycolysis This is an ancient pathway found in almost all living cells. In this pathway, a small amount of energy is generated as one glucose molecule is converted into two molecules of pyruvate.

Exogenous pyruvate plays a pivotal role in maintaining glycolysis–TCA cycle flux and ATP production under high-glucose conditions by suppressing PARP activity.

Two pathways that have a major role in glucose metabolism are the Embden–Meyerhof pathway and the tricarboxylic acid cycle (TCA). 6 The Embden–Meyerhof pathway metabolize glucose to pyruvate ...

image: Pyruvate is a key compound to many essential biological pathways that generate energy (TCA cycle, respiratory electron transfer, fatty acid oxidation) in E. coli.

Image Credit: EKF Diagnostics As the ultimate end product of glucose utilization within the body, lactate can be used in several ways. It can fuel the Krebs cycle once converted back to pyruvate ...

Chemical engineering researchers have created a new synthetic metabolic pathway for breaking down glucose that could lead to a 50 percent increase in the production of biofuels.

To address this, the research team used a small molecule called pyruvate, a naturally occurring byproduct of glucose. Pyruvate is small enough to cross the blood-brain barrier. In addition, it is well ...