Gene knockout approaches completely ablate gene expression at the DNA level. 3 Researchers can accomplish this by using genome editing tools, such as zinc finger nucleases (ZFN), transcription ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides valuable clues about what that gene normally does. However, creating and ...

Synthego, a leading genome engineering solutions company, today announced the launch of the Gene Knockout Kit v2. This is the only product that leverages a novel bioinformatics- powered multi-guide ...

To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...