Such method is called "Gene knockout." In contrast, in a "gene knockdown" scientists block protein production using particular substances, e.g. microRNAs. Recent studies, however, have shown that ...

The terms gene knockdown and gene knockout are often used interchangeably. However, there are some distinctions that may be made. Gene knockout is the total removal or permanent deactivation of a ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

The rapid adoption and ease of use of CRISPR-Cas9 has driven the development of applications for gene knockout, precise gene editing, and transcriptional regulation. This allows researchers to more ...

In traditional knockout studies, the gene is deleted altogether. However, deleting genes that are essential to embryonic development is lethal. Conditional gene knockout can be activated in an ...

Researchers have identified a cause for chronic bad breath (halitosis), with the help of gene knockout mice. An international team of researchers has identified a cause for chronic bad breath ...

For example, a knockout cell line for liver cancer might turn off a gene linked with tumor growth. Cancer isn’t directly passed down from parents to children the way some traits and health ...

Removing the PKCI/HINT1 gene from mice has an anti-depressant-like and anxiolytic-like effect. Researchers writing in the open access journal BMC Neuroscience applied a battery of behavioral tests to ...

A team at the UChicago-affiliated Marine Biological Laboratory has achieved the first gene knockout in a cephalopod using the squid Doryteuthis pealeii—an exceptionally important research organism in ...