"The promise of SBDD for GPCRs is that rational design can now be used to identify and optimise ligands that bind challenging or undruggable GPCR targets," said Fiona Marshall, Heptares' Chief ...

Methodological advances in X-ray crystallography have made possible the recent solution of X-ray structures of pharmaceutically important G protein-coupled receptors (GPCRs), including receptors for ...

This review explores how generative AI, through models like VAEs, GANs, transformers, and diffusion networks is ...

The companies will collaborate to prioritize the GPCR targets using Sosei Heptares’ world-leading StaR® (stabilized receptor) platform and structure-based drug design expertise, with the goal ...

"GPCR structure: Research reveals molecular origins of function for a key drug target." ScienceDaily. ScienceDaily, 21 December 2023. <www.sciencedaily.com / releases / 2023 / 12 / 231221162230.htm>.

In conclusion, the study suggests that machine learning-predicted structures, such as those generated by AlphaFold, can effectively identify GPCR ligands, accelerating drug discovery for novel ...

With coverage of design of TPDs, molecular glues, vaccines, antibodies, and mRNA, GPCRs and membrane protein targeting therapeutics plus much more! The field is evolving—don’t get left behind.