Is thymidylate synthase a reliable predictor for response and survival during hepatic arterial infusion for hepatic metastases from colorectal cancer?. Br J Cancer 95, 1304–1305 (2006). https ...

Background: 5-fluorouracil (5-FU), a synthetic fluoropyrimidine, is a critical component of chemotherapy in many cancers. Its metabolites inhibit Thymidylate Synthetase (TS) causing cessation of DNA ...

Cite this article Iacopetta, B., Elsaleh, H. Reply: Thymidylate synthase polymorphism and survival of colorectal cancer patients treated with 5-fluorouracil. Br J Cancer 86, 1366 (2002). https ...

Background: ALK+ NSCLC represents a molecular target-defined patient population highly responsive to the ALK inhibitor crizotinib. Previous reports have also suggested increased sensitivity of ALK+ ...