Thymidylate synthetase catalyzes the reductive methylation of 2'-deoxyuridylate (dUMP) to thymidylate (TMP) with the concomitant conversion of 5, 10-methylene tetrahydrofolate (CH 2 FAH 4 ) to 7, ...

Is thymidylate synthase a reliable predictor for response and survival during hepatic arterial infusion for hepatic metastases from colorectal cancer?. Br J Cancer 95, 1304–1305 (2006). https ...

Background: 5-fluorouracil (5-FU), a synthetic fluoropyrimidine, is a critical component of chemotherapy in many cancers. Its metabolites inhibit Thymidylate Synthetase (TS) causing cessation of DNA ...

Thymidylate synthase polymorphism and survival of colorectal cancer patients treated with 5-fluorouracil C M Ulrich & J D Potter British Journal of Cancer 86, 1365 (2002) Cite this article ...

The presence of dUMP in DNA from cells treated with methotrexate is a result of the great increase in intracellular concentration of dUTP and the fall in dTTP that accompany inhibition of thymidylate ...