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Nature22y
A “combination oligonucleotide” antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance
Thymidylate synthase (TS ... but effectively enhanced the cytotoxicity of raltitrexed and 5-FUdR (P Ferguson and R Berg, unpublished observations). The ODN combinations were then examined for ...
Nature18y
Is thymidylate synthase a reliable predictor for response and survival during hepatic arterial infusion for hepatic metastases from colorectal cancer?
Decreased levels of the target enzyme thymidylate synthase (TS) have been repeatedly associated with superior clinical outcome in gastrointestinal cancers, including stomach cancer. In the study ...