NEW YORK, August 15 (Praxis Press). Animal studies and some cohort studies in humans have raised concerns about the carcinogenicity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase ...

Aldose reductase, a key enzyme in the polyol pathway, catalyses the conversion of glucose to sorbitol, a process that becomes particularly problematic in hyperglycaemic conditions. Excessive flux ...

Trials on 5-alpha reductase inhibitors in prostate cancer prevention showed that they could significantly decrease the incidence of prostate cancer, but meanwhile increase high-grade cases as well.

As a folate-pathway inhibitor, MTX acts on one particular folate-pathway enzyme, namely dihydrofolate reductase (DHFR).

Jung Eun Lee, Esther K. Wei, Charles S. Fuchs, David J. Hunter, I-Min Lee, Jacob Selhub, Meir J. Stampfer, Walter C. Willett, Jing Ma, Edward Giovannucci, Plasma folate, methylenetetrahydrofolate ...

Compared to placebo treatment, taking 5-alpha-reductase inhibitors (5-ARIs) can reduce a man’s risk of being diagnosed with prostate cancer from around 5–9% to around 4-6% during up to 7 years ...