Use of multivitamin supplements containing folic acid diminished the adverse effects of dihydrofolate reductase inhibitors, but not that of antiepileptic drugs. Folic acid antagonists, which ...

a direct inhibitor of dihydrofolate reductase that indirectly inhibits purine synthesis by blocking the metabolism of folic acid; and allopurinol, which is used to treat hyperuricemia because it ...

Each group consists of drugs that prevent folic acid working in the body. One group (dihydrofolate reductase inhibitors) prevents folate from being converted into its active metabolites and ...

Two major trials have been performed to determine the effect of 5α-reductase inhibitors on subsequent ... such as increased insulin levels or folate depletion—that create a procarcinogenic ...

NEW YORK, August 15 (Praxis Press). Animal studies and some cohort studies in humans have raised concerns about the carcinogenicity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase ...

Using 5α- reductase inhibitors was not associated with increased suicide risk in a group of older men but risks for self-harm and depression were increased during the 18 months after medication ...