may also impair folate metabolism. “While research continues to come out, a small percentage of the population has a gene variant and may not properly metabolize folic acid,” says Schlichter.

"Folate helps to support the nitric oxide pathway, crucial for relaxing blood vessels and ensuring optimal blood flow, ...

Cellular Pathway of Methotrexate MTX affects enzymes in several important pathways, such as the folate and adenosine pathways involved in purine and pyrimidine metabolism within the cell.

Leucovorin is converted to folate in the brain by a different pathway, Siegel said. "Small studies are showing that it improves neurological function and communication skills in kids with ASD ...

Cellular Pathway of Methotrexate MTX affects enzymes in several important pathways, such as the folate and adenosine pathways involved in purine and pyrimidine metabolism within the cell.