Sulfasalazine is a powerful inhibitor of the reduced folate carrier, which in turn reduces cellular uptake of methotrexate. This explains why giving the drugs together is no better than giving MTX ...

Eight different vitamins make up the B complex, and they all play crucial roles in the body, such as producing energy, ...

The effect of folate status on breast cancer resistance protein (BCRP)-mediated drug resistance to epidermal growth factor receptor (EGFR)-targeted drugs, such as gefitinib and erlotinib, was ...

Eight different vitamins make up the B complex, and they all play crucial roles in the body, such as producing energy, ...

Researcher Lights The Way To Better Drug Delivery Date: September 21, 2006 Source: Purdue University Summary: A Purdue University researcher has explained for the first time the details of how ...

These nanoparticles carried multiple ligands, including E3 ligand, target protein ligand, and folate ligands on their surfaces. The binding of folate molecules on the nanoparticle surface to folate ...

A new vegetarian food that boosts the uptake of iron and offers a good set of proteins. The food, called tempe, is moreover a whole-grain product with high folate content. It is generally accepted ...

Mitochondria are the cellular powerplant, but their functions in conjunction with B-vitamins are only starting to be revealed. When nutrient status is good, vitamin B9, folate, turns mitochondria ...

A wild-type Datura innoxia cell line (P×4) was used to select methotrexate-resistant cells through a stepwise procedure. Two independently selected cell lines, MTX161 and MTX132, were stable and shown ...

We found that p70S6K and 4EBP1 differentially correlated with fatty acid uptake. We validated that cotargeting p70S6K and fatty acid metabolism synergistically inhibited cell proliferation.