Dihydropteroate synthase (DHPS) is a crucial enzyme in the folate biosynthetic pathway, catalysing the formation of essential folate cofactors that underpin DNA synthesis and cellular functioning.

Cysteine biosynthesis is a vital biochemical process that converts inorganic sulphur into organic forms, ultimately producing the sulphur‐containing amino acid cysteine. This amino acid is ...

The accompanying image illustrates the stages of enzyme activity of the first step of folate biosynthesis: free enzyme (orange), enzyme with substrate bound (salmon), and enzyme with pyrophosphate ...

The DHFR enzyme is currently targeted by methotrexate in anti-cancer therapies, by trimethoprim for antibacterial uses, and by pyrimethamine for anti-protozoal applications. An additional anti-folate ...

Researchers have stumbled on the identity of an enzyme that had been a mystery for more than 30 years. They discovered the missing part of the pathway in how bacteria make the B vitamin folate.

Our results establish that all enzymes of the folate biosynthesis pathway are active in the engineered fruit during ripening. However, GCHI protein and ADC synthase and lyase mRNAs are undetectable in ...

Folate and alcohol are dietary factors affecting the risk of cancer development in humans. The interaction between folate status and alcohol consumption in carcinogenesis involves multiple mechanisms.

6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), an enzyme from the folate biosynthesis pathway, catalyzes the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin and is a ...

Not so, it turns out, for Johns Hopkins researchers who have stumbled on the identity of an enzyme that had been a mystery for more than 30 years. The report appears in the May 15 issue of Structure.