coli with similar characteristics to ours that could initiate folate biosynthesis.” “So we had to ask, Can the bacteria make folate if we remove the orf17 gene"” says Amzel. Bessman and ...

These drugs are known to act by targeting specific steps in the folate biosynthetic pathway ... not just for Escherichia coli where our work was focused, but for pretty much all infectious ...

It plays a pivotal role in the biosynthesis of nucleotides, amino acids, and neurotransmitters. Deficiency of folic acid, rather than low bioavailability of the synthetic form, disrupts DNA repair ...

Advances have been made by upregulating key enzymes in the folate biosynthesis pathway, but challenges remain due to species-specific responses and the complex interaction of folate with cellular ...