Reference:Bhattacharya S, He Y, Chen Y, et al. Conformational dynamics and multimodal interaction of Paxillin with the focal adhesion targeting domain. Science Advances. 2025;11 (25):eadt9936. doi: 10 ...

S1-RBD supports cell adhesion and proliferation. A, FN-null MEFs (2.5×10 cells/cm) were seeded onto coverslips pre-coated with S1-RBD (500 nM) and cultured for 4 h prior to fixation and phase ...

The authors hypothesized that Cas could be a “signaling hub” for focal adhesion assembly. To evaluate the kinetics of Cas recruitment and tyrosine phosphorylation relative to focal adhesion assembly, ...

In a new study published in eLife, researchers reported that the adaptor protein Cas promoted the initiation of cellular adhesion, suggesting a force-independent activation. 4 Once activated through ...

However, the signaling mechanism of PTPRK remains to be determined. Here, we find that PTPRK regulates cell adhesion signaling, suppresses invasion, and promotes collective, directed migration in ...

To better understand paxillin’s role, the team turned to one of its main binding partners, known as focal adhesion kinase or FAK. The search has proved daunting.

Reference: Bhattacharya S, He Y, Chen Y, et al. Conformational dynamics and multimodal interaction of Paxillin with the focal adhesion targeting domain. Science Advances. 2025;11 (25):eadt9936. doi: ...