The results suggest a two-step model for focal adhesion assembly. “We show that integrin activation comprises two steps: first, phosphorylation of Cas and its recruitment to inactive integrin, which ...

More information: Wei-Wei Ren et al, MYO18B promotes lysosomal exocytosis by facilitating focal adhesion maturation, Journal of Cell Biology (2025). DOI: 10.1083/jcb.202407068 ...

Background: FAK transduces signaling from integrins and growth factors to modulate tumor cell invasion, proliferation and survival. PF-00562271 is a potent ATP-competitive inhibitor of FAK and proline ...

Contrary to what the terms cytoskeleton and focal adhesion suggest, these anchoring points are by no means static. During the movement of cells, for example, they are constantly dissolved and ...