The results suggest a two-step model for focal adhesion assembly. “We show that integrin activation comprises two steps: first, phosphorylation of Cas and its recruitment to inactive integrin, which ...

More information: Wei-Wei Ren et al, MYO18B promotes lysosomal exocytosis by facilitating focal adhesion maturation, Journal of Cell Biology (2025). DOI: 10.1083/jcb.202407068 ...

Focal adhesions are known as signalling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signalling cascades. However ...

Contrary to what the terms cytoskeleton and focal adhesion suggest, these anchoring points are by no means static. During the movement of cells, for example, they are constantly dissolved and ...

The research group from the Turku Bioscience Centre at the University of Turku in Finland unveiled the ultrastructure of focal adhesion scaffold using state-of-the-art super-resolution microscopy ...

Like wheels on a skateboard, these adhesions then give cells the ability to move around the body. The key to blocking this movement, says Anderson, is inhibiting the assembly of focal adhesions.

Background: PDAC is an aggressive cancer. It remains refractory to checkpoint inhibition because of its significant desmoplastic and immunosuppressive tumor microenvironment (TME). Focal adhesion ...