The new model is one of the most advanced constructs to represent the 3D architecture, composition and mechanics of native connective tissues like ligaments and tendons, the researchers said.

University researchers have developed a new connective tissue model to study disorders like fibrosis, a type of scarring that occurs when damage to the body causes normal tissue to be replaced by hard ...

For example, said Wilks, the data can be used to test whether an anti-fibrotic drug candidate stops the tissue stiffening that is characteristic of fibrotic diseases. “In this paper, we develop a 3D ...

More information: Katarzyna M. Sitnik et al, Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo, Nature Communications (2023).

The team has unveiled an innovative technique to convert fibroblasts - common connective tissue cells - into mature and functional induced cardiomyocytes (iCMs).

Peyronie’s disease is also caused by excess growth of fibroblasts, with deposition of collagen plaques in the penis, causing pain and deformity of the penis. This, in turn, can cause ...

Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity. eLife, 2021; 10 DOI: 10.7554/eLife.60745 ...