Bile acids are natural ligands of FXR, which bind to the ligand-binding pocket (LBP) in the ligand-binding domain (LBD) of FXR, inducing conformational changes that recruit co-activators and ...

University of Wisconsin–Madison researchers revealed how gut microbial bile acids impact colon cancer. One bile acid slows tumor growth by supporting the FXR protein, while another accelerates cancer ...

This perspective highlights the critical role of region-specific gut microbial distribution across intestinal segments (e.g., duodenum, colon) in ...

Bile acids are natural ligands of FXR, which bind to the ligand-binding pocket (LBP) in the ligand-binding domain (LBD) of FXR, inducing conformational changes that recruit co-activators and ...

Bile acid receptor could be innovative target in protecting the vision of premature newborns Go to source). By stimulating the farnesoid-X-receptor (FXR), a bile acid receptor, researchers believe ...

"Some microbial bile acids support FXR's function, while others antagonize it," says Ting Fu, an assistant professor in the UW–Madison School of Pharmacy.

In addition, bile acid metabolism is intimately involved with the microbiota, and bile acids have been shown to exhibit endocrine and metabolic activity via receptors like FXR and TGR5.

It’s called the farnesoid-X-receptor, or FXR, a bile acid receptor whose expression is significantly diminished in two key cell types affected by retinopathy of prematurity.

The farnesoid X receptor (FXR), a bile acid receptor, plays a direct role regulating innate immune cells in the gut, and treating mice with an FXR agonist improved symptoms of inflammatory bowel ...

The bile acid that supports the protein’s function slows the growth of cancer, while the bile acid that inhibits FXR acts as fuel for the tumors. These results were consistent across mouse models of ...