3d
News Medical on MSNFXR cyclic peptide antagonists as a novel strategy for MASH treatmentIn this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...
It has been shown that primary bile acids are capable of inducing cathelicidin gene expression in biliary epithelial cells through the FXR. Secondary bile acids that are byproducts of metabolism ...
The human gut is home to trillions of bacteria that play vital roles in digestion, immunity, and overall health. When this ...
FXR helps regulate several important processes in the body, such as metabolism and production of bile acid. By Ocaliva’s mechanism of action, FXR reduces how much bile is made from cholesterol.
highlighting the key roles of bile acid receptors, such as FXR and TGR5, in this process. Additionally, the gut-brain axis has been shown to be involved in the development of brain diseases in a ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results