Both of these pathways lead to the formation of thrombin. The extrinsic pathway also facilitates the transition of fibrinogen into fibrin and, ultimately, leads to clot formation.

Tissue-factor expression directly activates the extrinsic coagulation pathway and, via feedback loops, indirectly activates the intrinsic pathway. [12] ...

More information: Johannes Thaler et al, Saliva of persons with hemophilia A triggers coagulation via extrinsic tenase complexes, Blood (2024). DOI: 10.1182/blood.2024025093 ...

Saliva of persons with hemophilia A triggers coagulation via extrinsic tenase complexes. Blood, 2024; 144 (25): 2666 DOI: 10.1182/blood.2024025093 ...