Saliva of persons with hemophilia A triggers coagulation via extrinsic tenase complexes. Blood, 2024; 144 (25): 2666 DOI: 10.1182/blood.2024025093 ...

Tissue-factor expression directly activates the extrinsic coagulation pathway and, via feedback loops, indirectly activates the intrinsic pathway. [12] ...

Standard laboratory tests Standard laboratory blood tests for coagulation include prothrombin time, a measure of the extrinsic pathway of coagulation, and activated partial thromboplastin time, which ...

More information: Johannes Thaler et al, Saliva of persons with hemophilia A triggers coagulation via extrinsic tenase complexes, Blood (2024). DOI: 10.1182/blood.2024025093 ...

Thrombin stimulates the extrinsic coagulation pathway by activating factor V and helping to form the prothrombinase complex (Figure 1).