Extracellular cell matrix (ECM) plays a significant role in remodeling and stiffening during breast cancer progression. The rigid ECM impedes chemotherapeutic agent penetration into tumor cells.

Weiwei Wu ¹, Yan Lin ¹, Pandao Liu ¹², Qianqian Chen ¹, Jiang Tian ¹, Cuiyue Liang ¹, Association of extracellular dNTP utilization with a GmPAP1-like protein identified in cell wall proteomic ...

And how do mineral-dependent changes of their behavior regulate tumor cells?” Reference: Choi S, Whitman MA, Shimpi AA, et al. Bone-matrix mineralization dampens integrin-mediated mechanosignalling ...