The role of ITSN1, Intersectin-1, is to activate CDC42, a small Rho GTPase involved in the growth and maintenance of dopaminergic neurons and the regulation of vesicle exocytosis of α-synuclein ...
It reveals a pore complex with extended arms that could bind receptors involved in synaptic vesicle exocytosis. Perhaps these multiple actions are needed to cover the diversity of targets ...
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