After damage, lysosomes undergo extensive ubiquitylation that helps restore lysosomal function. ATXN3 with its partner p97 ...

For example, drug-tolerant ‘persister’ cancer cells can cause disease relapse after therapy. The accumulation of iron in organelles called lysosomes is a hallmark of these persister cells 1.

C-terminal fragments of amyloid precursor protein have been blamed for endolysosomal dysfunction in Alzheimer’s disease. Now, scientists led by Wim Annaert at KU Leuven, Belgium, claim that’s because ...