Duplication of a eukaryotic genome is a complex process that must be completed in a timely and accurate manner once each cell division cycle. Although much has been learned about the biochemical ...

DNA replication is a tightly controlled process. Several mechanisms have evolved to ensure that no regions of DNA are left unreplicated or are replicated more than once in every cell cycle.

6) It has been proposed that DNA replication takes place at replication foci, where replication factors are highly concentrated. Based on the authors' model that the localization of origins and ...

Whereas DNA replication in bacteria is typically initiated at a single sites, DNA replication in eukaryotes can be an immensely complicated multi-event affair, involving the coordinated initiation ...

Figure: Model of termination of eukaryotic DNA replication forks based on work conducted by groups of Johannes Walter, Karim Labib and Aga Gambus. We have identified the first elements of the ...

DNA replication is a tightly controlled process. Several mechanisms have evolved to ensure that no regions of DNA are left unreplicated or are replicated more than once in every cell cycle.