Dear Dr. Roach: I am a 70-year-old woman who has used Estrace vaginal cream weekly for several years. I’m in good health, work out daily, run half-marathons and have my own business.

My doctor prescribed Estrace cream suppository, which I do not want to use. I have no personal cancer, but I do have a family history of breast and ovarian cancer. C.M.

Used as a vaginal suppository, prasterone is converted into estradiol and testosterone, said Dr. JoAnn Pinkerton, a professor of obstetrics and gynecology in the University of Virginia Health ...