Scientists also found that the PGE2 molecule works by counteracting stem cell ageing. In the study, researchers examined the effects of PGE2 and its related molecule EP4 on the body.

In aged mice, scientists found that the EP4 production in muscle stem cells was either lacking, or reduced by half compared to levels found in young stem cells. “PGE2 is an alarm clock to wake ...

Prostaglandin E2 (PGE2) is produced via the action of the COX-2 enzyme, which can contribute to brain injury. In spite of the negative effects of COX-2, ongoing studies have shown that PGE2 can ...

In vitro and in vivo data show significant increased potency by blocking prostaglandin PGE2 signaling through both EP2 and EP4 receptors compared to celecoxib or single EP4 antagonists TPST-1495 ...

TPST-1495 is an orally-available small molecule designed to block the EP2 and EP4 receptors in the prostaglandin (PGE2) pathway, while sparing the homologous but differentially active EP1 and EP3 ...

The scientists began by examining the effects of PGE2 and its receptor EP4. Their prior research had established that PGE2 signals during muscle injury trigger muscle stem cells to regenerate the ...

In aged mice, scientists found that the EP4 production in muscle stem cells was either lacking, or reduced by half compared to levels found in young stem cells. “PGE2 is an alarm clock to wake up the ...