Only a fraction of the genes in a cell are expressed at any one time. The variety of gene expression profiles characteristic of different cell types arise because these cells have distinct sets of ...

Furthermore, EP4 gene ablation and EP4 blockade in cultured VSMCs were associated with a significant increase in MCP-1 and NOX1 expression and a marked reduction in α-SM actin (α-SMA), SM22α, and SM ...

Internal and external environmental factors, like gender and temperature, influence gene expression. Sex-limited traits are also autosomal. Unlike sex-influenced traits, whose expression differs ...

Objective: Excessive prostaglandin E2 production is a hallmark of abdominal aortic aneurysm (AAA). Enhanced expression of prostaglandin E2 receptor EP4 (prostaglandin E receptor 4) in vascular smooth ...

Abstract Prostaglandin EP4 receptor (EP4R) plays pivotal role in mediating PGE2-induced vasodilation and blood pressure homeostasis. Our previous work demonstrated that absence of EP4R in all tissues ...