Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been thought to depend on the energy obtained through glycolysis, a phenomenon ...

Model: Enrichment of glycolytic enzymes in self-organized glycolytic/F-actin waves enhance local glycolysis to provide energy for new wave formation, cell migration and other cellular processes.

At first glance, the result seems surprising, since the enzyme blockade inhibits the sugar degradation pathway in both cases. However, a closer look at the biochemical steps of glycolysis provides ...

In normal cells, the scientists observed almost no glycolytic enzymes in the cell surface or waves. "The more aggressive the cancer, the more waves we found on the cell surface," says Devreotes.

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport. Molecular Neurodegeneration, 2024; 19 (1) DOI: 10.1186/s13024-023-00690-9 ...

“Our results show that by inhibiting these enzymes, glucose cannot enter glycolysis, cutting off the parasite’s primary energy source.