It has long been thought that two enzymes, the kinases CDC7 and CDK2, are both needed to trigger DNA replication in mammalian cells. This view is challenged by evidence that offers a revised view ...

“These results strongly suggest that these mutations occur as APOBEC3G attacks cytosines during DNA replication, while they're most exposed on the lagging strand template,” Dr. Foster said.

The first step in replication is an enzyme called helicase that unwinds and “unzips” the double helix into two single strands. An enzyme called primase attaches a “primer” to each strand that allows ...

"Key role found for enzymes in DNA replication and sensitivity to chemotherapeutic drugs." ScienceDaily. ScienceDaily, 9 August 2018. <www.sciencedaily.com / releases / 2018 / 08 / 180809112516.htm>.

Evolutionarily conserved enzyme play key role in DNA replication Date: September 12, 2016 Source: Umea University Summary: Genome-wide studies of fission yeast (Schizosaccharomyces pombe) suggest ...

In addition to DNA polymerase, DNA replication also requires several other enzymes including a helicase to unwind the double-stranded template DNA, as well as a primase to assemble a short RNA primer.

They were studying DNA replication in cells raised under a limited supply of nucleotide bases that make up the A, T, C, and G letters of the DNA code. “You can think of it as your car running ...

LA JOLLA, CA - April 14, 2011 - An enzyme essential for DNA replication and repair in humans works in a way that might be exploited as anti-cancer therapy, say researchers at The Scripps Research ...

The DNA polymerase delta enzyme selects the right bases, and proofreads the sequences formed, as well as helping to repair the rare errors. The enzyme is composed of a core made up of p125 and P50 ...

The result: the enzymes that transcribe DNA can’t tell the difference between these synthetic base pairs and those found in nature. “In biology, structure determines function,” said Wang.

An INRS team discovers a new family of enzymes capable of inducing targeted cuts in single-stranded DNA A few years ago, the advent of technology known as CRISPR was a major breakthrough in the ...

News Release 9-Aug-2018 Key role found for enzymes in DNA replication and sensitivity to chemotherapeutic drugs Peer-Reviewed Publication Institute for Research in Biomedicine (IRB Barcelona) ...