It has long been thought that two enzymes, the kinases CDC7 and CDK2, are both needed to trigger DNA replication in mammalian cells. This view is challenged by evidence that offers a revised view ...

In addition to DNA polymerase, DNA replication also requires several other enzymes including a helicase to unwind the double-stranded template DNA, as well as a primase to assemble a short RNA primer.

“These results strongly suggest that these mutations occur as APOBEC3G attacks cytosines during DNA replication, while they're most exposed on the lagging strand template,” Dr. Foster said.

The DNA polymerase delta enzyme selects the right bases, and proofreads the sequences formed, as well as helping to repair the rare errors. The enzyme is composed of a core made up of p125 and P50 ...

Summary DNA modifying enzymes are a group of specialized proteins that play an essential role in the maintenance and expression of genetic information. These enzymes catalyze chemical reactions that ...

"Key role found for enzymes in DNA replication and sensitivity to chemotherapeutic drugs." ScienceDaily. ScienceDaily, 9 August 2018. <www.sciencedaily.com / releases / 2018 / 08 / 180809112516.htm>.

LA JOLLA, CA - April 14, 2011 - An enzyme essential for DNA replication and repair in humans works in a way that might be exploited as anti-cancer therapy, say researchers at The Scripps Research ...

The first step in replication is an enzyme called helicase that unwinds and “unzips” the double helix into two single strands. An enzyme called primase attaches a “primer” to each strand that allows ...

An enzyme called primase attaches a "primer" to each strand that allows replication to start, then another enzyme called DNA polymerase attaches at the primer and moves along the strand adding new ...

News Release 9-Aug-2018 Key role found for enzymes in DNA replication and sensitivity to chemotherapeutic drugs Peer-Reviewed Publication Institute for Research in Biomedicine (IRB Barcelona) ...