Enzymes are vital to metabolism and drive countless biological processes in humans, plants, and industry. Yet, when ...

Exo Therapeutics raised $78 million in series B financing to develop a new strategy for drugging enzymes. Many drugs work by blocking target enzymes’ active sites, which perform reactions like ...

The “lock and key” model was first proposed in 1894. In this model, an enzyme’s active site is a specific shape, and only the substrate will fit into it, like a lock and key.

Weizmann Institute of Science-led researchers have unveiled a computational workflow that crafts enzymes exhibiting catalytic efficiencies surpassing 100,000 M−1 s−1, achieving performance comparable ...

R. Rogers Yocum, David J. Waxman, James R. Rasmussen, Jack L. Strominger, Mechanism of Penicillin Action: Penicillin and Substrate Bind Covalently to the Same Active Site Serine in Two Bacterial ...