The vesicle is then quickly merged with an endosome, an organelle also frequently referred to as a “sorting station”. From the endosome, the substance is either recycled back to the cell membrane (for ...

“AP1M1 absence strongly increases ASO activity by delaying endosome-to-lysosome transport in vitro and in vivo. Prolonged ASO residence time in the endosomal system may increase the likelihood ...

(6) Lysosomes directly take up mitochondria by the lysosomal membrane invagination. (7) Endosome/pre-lysosome directly ‘hit and run’ with mitochondria or MDV to form mitochondria-lysosome ...

RAB7A plays a central role in the final stages of autophagy, facilitating autophagosome-lysosome fusion, lysosome positioning, and cargo degradation. Its activation by guanine nucleotide exchange ...

Endocytosis and degradation of the membrane receptors in the lysosome controls the activation of intracellular signaling pathways, but the mechanisms that control the endocytosis itself are largely ...

These results indicate a delay in endosome-to-lysosome maturation, with lysosomes failing first. Calcium levels in lysosomes also fell by 30 percent in the 24 hours after DAPT. Bretou saw the same ...

“We feel quite happy we were able to reveal this constant conversion rate.” Diao noted that for the first time, the team found this process from endosome to lysosome is governed by a complicated ...