More information: Marine Bretou et al, Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites ...

Materials marked for degradation are passed to late endosomes and eventually to lysosomes ... which plays a vital role in regulating endosome maturation. This gene encodes a deubiquitinating ...

(6) Lysosomes directly take up mitochondria by the lysosomal membrane invagination. (7) Endosome/pre-lysosome directly ‘hit and run’ with mitochondria or MDV to form mitochondria-lysosome ...