“AP1M1 absence strongly increases ASO activity by delaying endosome-to-lysosome transport in vitro and in vivo. Prolonged ASO residence time in the endosomal system may increase the likelihood ...

Endocytosis and degradation of the membrane receptors in the lysosome controls the activation of intracellular signaling pathways, but the mechanisms that control the endocytosis itself are largely ...

RAB7A plays a central role in the final stages of autophagy, facilitating autophagosome-lysosome fusion, lysosome positioning, and cargo degradation. Its activation by guanine nucleotide exchange ...

These results indicate a delay in endosome-to-lysosome maturation, with lysosomes failing first. Calcium levels in lysosomes also fell by 30 percent in the 24 hours after DAPT. Bretou saw the same ...

Escaping the endosome: Bend lipids improve LNP mRNA delivery and gene editing Date: January 28, 2025 Source: University of Pennsylvania School of Engineering and Applied Science Summary: A new ...