More information: Biplab Kumar Dash et al, Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-mediated autophagy and specialized SNARE complex, Proceedings of the National ...

More information: Isidoro Cobo et al, Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression, Immunity ...

They then found that STK38 works with a protein complex called the "endosomal sorting complex required for transport (ESCRT) machinery," which was already known to be linked to lysosomal repair.

The LAMTOR [late endosomal and lysosomal adaptor and MAPK (mitogen-activated protein kinase) and mTOR (mechanistic target of rapamycin) activator] complex, also known as “Ragulator,” controls the ...

They then found that STK38 works with a protein complex called the “endosomal sorting complex required for transport (ESCRT) machinery”, which was already known to be linked to lysosomal repair.

Acid-sensitive nanoparticles that are prone to swelling, dissolution or degradation at endosomal/lysosomal pH (4.0–6.5) have been devised to obtain fast intracellular DOX release in tumor cells.

They then found that STK38 works with a protein complex called the "endosomal sorting complex required for transport (ESCRT) machinery", which was already known to be linked to lysosomal repair.

The pathways that determine these different disease outcomes are still ill-defined, noted David Sulzer of Columbia University Medical Center, New York, who was not involved in either study. “This is a ...

Niemann-Pick disease Type C is a progressive, life-limiting neurological lysosomal storage disorder caused by mutations in the NPC1 or NPC2 gene and aberrant endosomal-lysosomal trafficking ...

This study explores the role of endosomal PI (4,5)P2 catabolism in innate immunity, using C. elegans as a model organism. The research highlights how RAB-10 and its effector UNC-16 regulate DAG ...