The body's endogenous opioid system has three classes of opioid receptors: mu, delta, and kappa. Previous research showed that mice lacking the mu opioid receptor do not drink alcohol. A new study ...

Creating such a peptide will bind the opioid receptors subtypes in the same fashion our own endogenous opioids does has the potential results of alleviating the pain without creating the undesired ...

"Lowered Endogenous Mu-Opioid Receptor Availability in Subclinical Depression and Anxiety." Neuropsychopharmacology (First published: May 30, 2020) DOI: 10.1038/s41386-020-0725-9 ...

Opioids produce analgesia via mu-opioid receptor (MOR) mechanisms. These receptors are like docking stations that also bind with natural, self-produced analgesics such as endorphins and endogenous ...

These receptors normally respond to naturally-produced chemicals that are released in your brain, called endogenous opioids, including endorphins, enkephalins, and dynorphins.

These receptors normally respond to naturally-produced chemicals that are released in your brain, called endogenous opioids, including endorphins, enkephalins, and dynorphins.

Because of that, they seem to leave the receptor on and yet still receptive to endogenous opioids," says Bohn, who chairs the Scripps Research Department of Molecular Medicine in Jupiter, Florida.

Synthetic opioid drugs, such as morphine and fentanyl, are the most powerful class of painkilling drugs available. Women are known to respond poorly to opioid therapies, which use synthetic opioid ...

The results of studies in mice with loss of melanocortin 1 receptor (MC1R) function could help point to new ways to manipulate the body’s natural mechanisms for controlling pain perception, for ...

One side effect of naloxone is intense symptoms of opioid withdrawal, but although compound 368 enhances most of naloxone’s actions, it does not seem to enhance withdrawal symptoms.