In previous reports, we showed that βig-h3 mediates cell adhesion and migration and, especially in bones, negatively regulates the mineralization in the end stage of endochondral ossification.

C-type natriuretic peptide, encoded by NPPC, and its receptor, natriuretic peptide receptor 2 (NPR2), are potent stimulators of endochondral ossification. 20 Reduced Nppc or Npr2 expression, or ...