EBF1 is a key determinant of a transcriptional regulatory network involved in establishing the B cell fate by activating lineage-specific gene expression and repressing genes associated with ...

Significance We demonstrated that early B cell factor 1 (EBF1) is highly expressed in triple-negative breast cancer (TNBC) cells, and knockdown of EBF1 blocks TNBC cell growth and invasiveness. EBF1 ...

Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells. Nature Immunology, 2013; 14 (8): 867 DOI: 10.1038/ni.2641 ...

Ebf1 accomplishes this through both direct negative regulation of Foxo1 expression and direct positive regulation of Gfi1b expression. Ebf1 expression is driven by the IL-7R downstream effector Stat5, ...

Rudolf Grosschedl and his colleagues were able to prove as early as 1995 that the transcription factor EBF1 is active only in some of these cells and this induces their development into B cells. Until ...

Early B cell factor 1 (EBF1) has been identified as an upstream transcription factor of the potential oncogene PNO1 and is involved in the growth of colorectal cancer (CRC) cells. However, its ...

EBF1, MYO6 and CALR expression levels predict therapeutic response in diffuse large B-cell lymphomas Alice Turdo 1† Miriam Gaggianesi 2† Caterina D’Accardo 1 Gaetana Porcelli 1 Sebastiano Di Bella 2 ...

In the current study, researchers identified a gene, EBF1, which according to these new findings drive the development of the unhealthy adipose tissue.

EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development Journal: Journal of Neuroscience Published: 2024-02-14 DOI: ...