Type 2 diabetes (T2D) is a global metabolic epidemic driven by insulin resistance (IR), chronic inflammation, and β-cell ...

Type 2 diabetes (T2D) is a global metabolic epidemic driven by insulin resistance (IR), chronic inflammation, and β-cell failure. This review ...

Mechanistically, CPI-613 induces endoplasmic reticulum (ER) stress and triggers the expression level of XBP1s, which transcriptionally suppresses the expression of THBS2 gene. In addition, THBS2 ...

We are grateful to know the proportion of weakly positive ER cases in this study. In addition to this, approximately 10% of patients were previously treated with SERD. Amcenestrant may not be ...